Erratum: A closely linked genetic marker for cystic fibrosis
نویسندگان
چکیده
منابع مشابه
Cystic fibrosis--a genetic dilemma.
Cystic fibrosis is a common genetic disease that usually presents in early childhood as a devastating disease affecting pulmonary function and at times gastrointestinal functioning and nutritional status. Variant forms of this disease have been described, which may have a delayed age of onset or a milder clinical course. Numerous genetic mutations have been described in cystic fibrosis. There a...
متن کاملDinucleotide repeat polymorphism closely linked to the cystic fibrosis (CFTR) gene.
Source/Description: A polymorphic region consisting of repeats of the dinucleotide (GT), was identified with a (CA),0 oligonucleotide probe in a cosmid (1) containing the KM. 19 and CS.7 probe fragments near the CFTR gene (2). A fragment containing the polymorphic region, and lying approximately 3 kb centromeric to the CS.7 probe fragment (3), was cloned and sequenced (EMBL # X60680) to reveal ...
متن کاملCharacterization and rapid diagnostic analysis of DNA polymorphisms closely linked to the cystic fibrosis locus.
Six genetic polymorphisms, closely linked to the cystic fibrosis gene and useful in clinical linkage analysis, have been characterized and converted to a more rapid form of assay. Sequences flanking the metD (Ban I), metH (Msp I), XV-2c (Taq I), KM.19 (Pst I), MP6d-9 (Msp I), and J3.11 (Msp I) polymorphic restriction sites have been determined and used to design specific polymerase chain reacti...
متن کاملCystic fibrosis locus defined by a genetically linked polymorphic DNA marker.
A polymorphic DNA marker has been found genetically linked, in a set of 39 human families, to an autosomal recessive gene that causes cystic fibrosis (CF), a disease affecting one in 2000 Caucasian children. The DNA marker (called D0CRI-917) is also linked to the PON locus, which by independent evidence is linked to the CF locus. The best estimates of the genetic distances are 5 centimorgans be...
متن کاملAnalysis of c.3369+213TA[7-56] and D7S523 microsatellites linked to Cystic Fibrosis Transmembrane Regulator.
Cystic fibrosis (CF) is a life-limiting autosomal recessive disorder affecting principally respiratory and digestive system . It is caused by cystic fibrosis transmembrane conductance regulator (CFTR) gene mutation. The aim of this study was to determine the extent of repeat numbers and the degree of heterozygosity for c.3499+200TA(7_56) and D7S523 located in intron 17b and 1 cM proximal to t...
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ژورنال
عنوان ژورنال: Nature
سال: 1986
ISSN: 0028-0836,1476-4687
DOI: 10.1038/319160a0